https://scholars.lib.ntu.edu.tw/handle/123456789/637226
標題: | Mir125b-1 is Not Imprinted in Human Brain and Shows Developmental Expression Changes in Mouse Brain | 作者: | Hou, Kuan-Chu Tsai, Meng-Han Akbarian, Schahram HSIEN-SUNG HUANG |
關鍵字: | genomic imprinting; human brain; microRNA; mouse brain | 公開日期: | 1-十月-2023 | 出版社: | Elsevier Ltd | 卷: | 529 | 起(迄)頁: | 99 | 來源出版物: | Neuroscience | 摘要: | Genomic imprinting is a predominantly brain and placenta-specific epigenetic process that contributes to parent-of-origin-specific gene expression. While microRNAs are highly expressed in the brain, their imprinting status in this tissue remains poorly studied. Previous research demonstrated that Mir125b-2 is imprinted in the human brain and regulates hippocampal circuits and functions in mice. However, the imprinting status of another isoform of miR125b, Mir125b-1, in the human brain, as well as its spatiotemporal expression patterns in mice, have not been elucidated. Here, we show MIR125B1 is not imprinted in the human brain. Moreover, miR-125b-1 was highly expressed in the brains of mice. Furthermore, miR-125b-1 was down-regulated during brain development in mice. Specifically, miR-125b-1 displayed preferential expression in the olfactory bulb, thalamus, and hypothalamus of the mouse brain. Notably, miR-125b-1 was enriched in GABAergic neurons, particularly somatostatin-expressing GABAergic neurons, compared with glutamatergic neurons. Taken together, our findings provide the imprinting status and comprehensive spatiotemporal expression profiling of Mir125b-1 in the brain. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637226 | ISSN: | 03064522 | DOI: | 10.1016/j.neuroscience.2023.08.014 |
顯示於: | 腦與心智科學研究所 |
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