https://scholars.lib.ntu.edu.tw/handle/123456789/637261
標題: | Increased plasma DR-70 (fibrinogen-fibrin degradation products) concentrations as a diagnostic biomarker in dogs with neoplasms | 作者: | Ke, Chiao Hsu Sio, Ka Mei Wu, Chun Hung Xia, Yuan Yuan JIH-JONG LEE Hu, Chin Hao Liu, Cheng Chi Lu, Chueh Ling Cheng, Chiao Lei Lin, Keng Hsuan Tomiyasu, Hirotaka Wang, Yu Shan CHEN-SI LIN |
關鍵字: | biomarker | DR-70 | fibrinogen-fibrin degradation products | tumor detection | 公開日期: | 1-一月-2023 | 卷: | 37 | 期: | 6 | 起(迄)頁: | 2391 - 2401 | 來源出版物: | Journal of Veterinary Internal Medicine | 摘要: | Background: Tumor biomarkers have used widely in clinical oncology in human medicine. Only a few studies have evaluated the clinical utility of tumor biomarkers for veterinary medicine. A test for fibrinogen and fibrin degradation products (DR-70) has been proposed as an ideal biomarker for tumors in humans. The clinical value of DR-70 for veterinary medicine however has yet to be determined. Objectives: Investigate the diagnostic value of DR-70 concentrations by comparing them between healthy dogs and dogs with tumors. Animals: Two hundred sixty-three dogs with different types of tumors were included. Sixty healthy dogs also were recruited for comparison. Methods: The DR-70 concentrations were measured in all recruited individuals by ELISA. Clinical conditions were categorized based on histopathology, cytology, ultrasound examination, radiology, clinical findings, and a combination of these tests. Results: The median concentration of DR-70 was 2.130 ± 0.868 μg/mL in dogs with tumors, which was significantly higher than in healthy dogs (1.202 ± 0.610 μg/mL; P <.0001). With a cut-off of 1.514 μg/mL, the sensitivity and specificity of DR-70 were 84.03% and 78.33%, respectively. The area under curve was 0.883. The DR-70 concentration can be an effective tumor biomarker in veterinary medicine. Conclusions and Clinical Importance: Increased DR-70 concentrations were not affected by tumor type, sex, age, or body weight. However, in dogs with metastatic mast cell tumors and oral malignant melanoma, DR-70 concentrations were significantly increased. Additional studies, including more dogs with nonneoplastic diseases, are needed to further evaluate the usefulness of DR-70 as a tumor biomarker. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174024082&doi=10.1111%2fjvim.16898&partnerID=40&md5=cbb28fc1c0b28593275a9e3b4bb70173 https://scholars.lib.ntu.edu.tw/handle/123456789/637261 |
ISSN: | 08916640 | DOI: | 10.1111/jvim.16898 |
顯示於: | 獸醫學系 |
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