https://scholars.lib.ntu.edu.tw/handle/123456789/637299
標題: | An expert system to classify microarray gene expression data using gene selection by decision tree | 作者: | Horng, Jorng Tzong Wu, Li Cheng Liu, Baw Juine Kuo, Jun Li WEN-HUNG KUO Zhang, Jin Jian |
關鍵字: | Bioinformatics | Decision tree | Expert system | Machine learning | Microarray gene expression | 公開日期: | 1-七月-2009 | 卷: | 36 | 期: | 5 | 來源出版物: | Expert Systems with Applications | 摘要: | Gene selection can help the analysis of microarray gene expression data. However, it is very difficult to obtain a satisfactory classification result by machine learning techniques because of both the curse-of-dimensionality problem and the over-fitting problem. That is, the dimensions of the features are too large but the samples are too few. In this study, we designed an approach that attempts to avoid these two problems and then used it to select a small set of significant biomarker genes for diagnosis. Finally, we attempted to use these markers for the classification of cancer. This approach was tested the approach on a number of microarray datasets in order to demonstrate that it performs well and is both useful and reliable. © 2008 Elsevier Ltd. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637299 | ISSN: | 09574174 | DOI: | 10.1016/j.eswa.2008.12.037 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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