https://scholars.lib.ntu.edu.tw/handle/123456789/637386
標題: | Fenpropathrin causes alterations in locomotion and social behaviors in zebrafish (Danio rerio) | 作者: | Liu, Sian-Tai Horng, Jiun-Lin Lin, Li-Yih MING-YI CHOU |
關鍵字: | Dopaminergic neurons; Fenpropathrin; Locomotion; Zebrafish | 公開日期: | 十二月-2023 | 出版社: | Elsevier B.V. | 卷: | 265 | 期: | Article number 106756 | 來源出版物: | Aquatic Toxicology | 摘要: | Fenpropathrin is one of the widely used pyrethroid pesticides in agriculture and is frequently detected in the environment, groundwater, and food. While fenpropathrin was found to have neurotoxic effects in mammals, it remains unclear whether it has similar effects on fish. Here, we used adult zebrafish to investigate the impacts of fenpropathrin on fish social behaviors and neural activity. Exposure of adult zebrafish to 500 ppb of fenpropathrin for 72 h increased anxiety levels but decreased physical fitness, as measured by a novel tank diving test and swimming tunnel test. Fish exposed to fenpropathrin appeared to spend more time in the conspecific zone of the tank, possibly seeking greater comfort from their companions. Although learning, memory, and aggressive behavior did not change, fish exposed to fenpropathrin appeared to have shorter fighting durations. The immunocytochemical results showed the tyrosine hydroxylase antibody-labeled dopaminergic neurons in the teleost posterior tuberculum decreased in the zebrafish brain. According to a quantitative polymerase chain reaction (qPCR) analysis of the brain, exposure to fenpropathrin resulted in a decrease in the messenger (m)RNA expression of monoamine oxidase (mao), an enzyme that facilitates the deamination of dopamine. In contrast, the mRNA expression of the sncga gene, which may trigger Parkinson's disease, was found to have increased. There were no changes observed in expressions of genes related to antioxidants and apoptosis between the control and fenpropathrin-exposed groups. We provide evidence to demonstrate the defect of the neurotoxicity of fenpropathrin toward dopaminergic neurons in adult zebrafish. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637386 | ISSN: | 0166445X | DOI: | 10.1016/j.aquatox.2023.106756 |
顯示於: | 生命科學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。