https://scholars.lib.ntu.edu.tw/handle/123456789/637474
標題: | Structure and replication of the genome of the hepatitis δ virus | 作者: | PEI-JER CHEN Kalpana, G. Goldberg, J. Mason, W. Werner, B. Gerin, J. Taylor, J. |
公開日期: | 1-十二月-1986 | 卷: | 83 | 期: | 22 | 來源出版物: | Proceedings of the National Academy of Sciences of the United States of America | 摘要: | The hepatitis δ virus can be found in the serum and liver of some hepatitis B virus patients. We now report that the RNA genome of serum-derived δ virus is single-stranded and circular. Livers of infected chimpanzees or woodchucks contained as many as 300,000 copies of genomic strand RNA per average cell, and at least some of this RNA had a circular conformation. Also present in the liver were RNA species complementary to the virion RNA. The genomic RNA was 5-22 times more abundant than this antigenomic strand. Some of the antigenomic RNA was complexed with genomic RNA, as evidenced by the fact that at least 34% of the antigenomic RNA was resistant to digestion with either RNase A in 0.3 M NaCl or S1 nuclease. Some of the antigenomic RNA was in a circular conformation. These and other findings showed that the structure and replication of hepatitis δ virus are in many ways similar to those of the previously described plant viroids, virusoids, and satellite RNAs. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637474 | ISSN: | 00278424 | DOI: | 10.1073/pnas.83.22.8774 |
顯示於: | 臨床醫學研究所 |
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