https://scholars.lib.ntu.edu.tw/handle/123456789/637799
標題: | Improvement After Celecoxib Treatment in Patients with Thalamic Hemorrhage - A Case Report | 作者: | Lin, Yu-Wei SHIN-JOE YEH SUNG-CHUN TANG LI-KAI TSAI JIANN-SHING JENG |
關鍵字: | Brain edema; Celecoxib; Intracerebral hemorrhage. | 公開日期: | 30-十二月-2022 | 卷: | 31 | 期: | 4 | 起(迄)頁: | 161 | 來源出版物: | Acta neurologica Taiwanica | 摘要: | Perihematomal edema of intracerebral hemorrhage (ICH) is caused by a hematoma-induced inflammatory reaction, which usually contributes to delayed deterioration of neurological function and poor outcomes. Celecoxib is a commonly used nonsteroidal anti-inflammatory drug that selectively inhibits cyclooxygenase-2. High-dose celecoxib (400 mg twice daily) for 14 days has been shown to reduce perihematomal edema and hematoma enlargement in patients with ICH, but without improvement in long-term functional outcome, which may be confounded by the heterogeneity of hematoma location. Low-dose celecoxib may be an effective management for symptoms caused by perihematomal edema in patients with ICH, particularly those involving the thalamus. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637799 | ISSN: | 1028-768X |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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