https://scholars.lib.ntu.edu.tw/handle/123456789/638015
標題: | Identification of three capsule depolymerases in a bacteriophage infecting Klebsiella pneumoniae capsular types K7, K20, and K27 and therapeutic application | 作者: | Wu, Jia-Wen JIN-TOWN WANG Lin, Tzu-Lung Liu, Ya-Zhu Wu, Lii-Tzu Pan, Yi-Jiun |
關鍵字: | Capsule depolymerase; Hypervirulent; Klebsiella pneumoniae; Phage | 公開日期: | 20-五月-2023 | 卷: | 30 | 期: | 1 | 來源出版物: | Journal of biomedical science | 摘要: | Klebsiella pneumoniae capsular types K1, K2, K5, K20, K54, and K57 are prevalent hypervirulent types associated with community infections, and worrisomely, hypervirulent strains that acquired drug resistance have been found. In the search for alternative therapeutics, studies have been conducted on phages that infect K. pneumoniae K1, K2, K5, and K57-type strains and their phage-encoded depolymerases. However, phages targeting K. pneumoniae K20-type strains and capsule depolymerases capable of digesting K20-type capsules have rarely been reported. In this study, we characterized a phage that can infect K. pneumoniae K20-type strains, phage vB_KpnM-20. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/638015 | ISSN: | 10217770 | DOI: | 10.1186/s12929-023-00928-0 |
顯示於: | 微生物學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。