An HSP90 cochaperone Ids2 maintains the stability of mitochondrial DNA and ATP synthase
Journal
BMC biology
Journal Volume
19
Journal Issue
1
Date Issued
2021-11-11
Author(s)
Abstract
Proteostasis unbalance and mitochondrial dysfunction are two hallmarks of aging. While the chaperone folds and activates its clients, it is the cochaperone that determines the specificity of the clients. Ids2 is an HSP90's cochaperone controlling mitochondrial functions, but no in vivo clients of Ids2 have been reported yet.
Subjects
ATP synthase; Aging; Ids2; Mitochondria; Proteostasis
SDGs
Type
journal article