https://scholars.lib.ntu.edu.tw/handle/123456789/638028
標題: | Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process | 作者: | SHU-CHUN TENG Chang, Jason McCowan, Bradley Zakian, Virginia A. |
公開日期: | 1-一月-2000 | 卷: | 6 | 期: | 4 | 來源出版物: | Molecular Cell | 摘要: | Type II survivors arise in Saccharomyces cells lacking telomerase by a recombinational pathway that results in very long and heterogeneous length telomeres. Here we show that type II telomeres appeared abruptly in a population of cells with very short telomeres. Once established, these long telomeres progressively shortened. Short telomeres were substrate for rare, one-step lenthening events. The generation of type II survivors was absolutely Rad50p dependent. In a telomerase-proficient cell, the telomere-binding Rif proteins inhibited telomerase lengthening of telomeres. In a telomerase-deficient strain, Rif proteins, especially Rif2p, inhibited type II recombination. These data argue that only short telomeres are substrates for type II recombination and suggest that the donor for this recombination is not a chromosomal telomere. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/638028 | ISSN: | 10972765 | DOI: | 10.1016/S1097-2765(05)00094-8 |
顯示於: | 微生物學科所 |
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