https://scholars.lib.ntu.edu.tw/handle/123456789/638180
標題: | Epigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions | 作者: | Kawakatsu, Taiji Huang, Shao-Shan Carol Jupe, Florian Sasaki, Eriko Schmitz, Robert J Urich, Mark A Castanon, Rosa Nery, Joseph R Barragan, Cesar He, Yupeng Chen, Huaming Dubin, Manu CHENG-RUEI LEE Wang, Congmao Bemm, Felix Becker, Claude O'Neil, Ryan O'Malley, Ronan C Quarless, Danjuma X Schork, Nicholas J Weigel, Detlef Nordborg, Magnus Ecker, Joseph R |
公開日期: | 14-七月-2016 | 卷: | 166 | 期: | 2 | 來源出版物: | Cell | 摘要: | The epigenome orchestrates genome accessibility, functionality, and three-dimensional structure. Because epigenetic variation can impact transcription and thus phenotypes, it may contribute to adaptation. Here, we report 1,107 high-quality single-base resolution methylomes and 1,203 transcriptomes from the 1001 Genomes collection of Arabidopsis thaliana. Although the genetic basis of methylation variation is highly complex, geographic origin is a major predictor of genome-wide DNA methylation levels and of altered gene expression caused by epialleles. Comparison to cistrome and epicistrome datasets identifies associations between transcription factor binding sites, methylation, nucleotide variation, and co-expression modules. Physical maps for nine of the most diverse genomes reveal how transposons and other structural variants shape the epigenome, with dramatic effects on immunity genes. The 1001 Epigenomes Project provides a comprehensive resource for understanding how variation in DNA methylation contributes to molecular and non-molecular phenotypes in natural populations of the most studied model plant. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/638180 | ISSN: | 00928674 | DOI: | 10.1016/j.cell.2016.06.044 |
顯示於: | 植物科學研究所 |
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