https://scholars.lib.ntu.edu.tw/handle/123456789/638307
標題: | Nano-modified viruses prime the tumor microenvironment and promote the photodynamic virotherapy in liver cancer | 作者: | DA-LIANG OU Liao, Zi-Xian Kempson, Ivan M Li, Lin PAN-CHYR YANG Tseng, S-Ja |
關鍵字: | Adeno-associated virus; Immune-promoting effect; Iron oxide nanoparticles; Macrophage; Orthotopic hepatocellular carcinoma; Photodynamic virotherapy | 公開日期: | 2-一月-2024 | 卷: | 31 | 期: | 1 | 來源出版物: | Journal of biomedical science | 摘要: | As of 2020, hepatocellular carcinoma (HCC), a form of liver cancer, stood as the third most prominent contributor to global cancer-related mortality. Combining immune checkpoint inhibitors (ICI) with other therapies has shown promising results for treating unresectable HCC, offering new opportunities. Recombinant adeno-associated viral type 2 (AAV2) virotherapy has been approved for clinical use but it efficacy is stifled through systemic administration. On the other hand, iron oxide nanoparticles (ION) can be cleared via the liver and enhance macrophage polarization, promoting infiltration of CD8+ T cells and creating a more favorable tumor microenvironment for immunotherapy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/638307 | ISSN: | 10217770 | DOI: | 10.1186/s12929-023-00989-1 |
顯示於: | 腫瘤醫學研究所 |
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