https://scholars.lib.ntu.edu.tw/handle/123456789/638358
標題: | A pH-sensitive EVAL membrane by blending with PAA | 作者: | Lai, Ping Shan MING-JIUM SHIEH Pai, Chin Ling Wang, Cheng Yi Young, Tai-Horng |
關鍵字: | Blending | EVAL | PAA | pH-sensitive | 公開日期: | 20-四月-2006 | 卷: | 275 | 期: | 1-2 | 來源出版物: | Journal of Membrane Science | 摘要: | The purpose of this study was to produce pH-sensitive domain in the dense poly(ethylene-co-vinyl-alcohol) (EVAL) membrane for colonic delivery of anti-cancer drug 5-fluorouracil (5-FU) by blending with a small amount of poly(acrylic acid) (PAA). The Fourier transform infrared (FTIR) spectroscopy analysis shows that PAA and EVAL were not very compatible in the PAA/EVAL blended membrane, whereas the intensity of self-association of both polymers was higher than that of inter-association between PAA and EVAL. It was proposed that PAA molecules would aggregate to act as the access for the transport of 5-FU through the blended membranes. The aggregated PAA gel phases were beyond the observable sensitivity of the scanning electron microscopy (SEM) and were low permeable for 5-FU at low pH, but significantly improved the permeability of 5-FU by the increase of pH of the medium, which agreed with the application of colon-specific drug delivery. When the membrane preparation temperature was changed from 60 to 45°C, PAA domain contained in the blended membrane did not affect the permeation rate of 5-FU at different pH. This is because the membrane prepared at 45°C was not so dense as that prepared at 60°C. Therefore, the pH-sensitive characteristic of PAA domains would be applicable only to the membrane with a dense structure. Finally, it was demonstrated that 5-FU separated by the blended membranes still exhibited cytotoxicitiy toward Caco-2 cells at pH 7.4. Thus, the PAA/EVAL blended membrane is a potential material for the specific delivery of 5-FU to the colon for local treatment of colorectal cancer in the future clinical application. © 2005 Elsevier B.V. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/638358 | ISSN: | 03767388 | DOI: | 10.1016/j.memsci.2005.09.007 |
顯示於: | 醫學系 |
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