https://scholars.lib.ntu.edu.tw/handle/123456789/638361
標題: | Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles | 作者: | Peng, Cheng-Liang Lai, Ping-Shan Lin, Feng-Huei Yueh-Hsiu Wu, Steven MING-JIUM SHIEH |
關鍵字: | Chemotherapy | Colon cancer | Micelle | Photodynamic therapy | SN-38 | Star-shaped copolymer | 公開日期: | 七月-2009 | 卷: | 30 | 期: | 21 | 來源出版物: | Biomaterials | 摘要: | Chlorin-core star-shaped block copolymer (CSBC) may self-assemble to form micelles, which act as nanosized photosensitizing agents for photodynamic therapy (PDT) and further encapsulate hydrophobic drugs. This functionalized micellar delivery system is a potential dual carrier for the synergistic combination of photodynamic therapy and chemotherapy for the treatment of cancer. In this study, SN-38 encapsulated CSBC micelles were successfully prepared using a lyophilization-hydration method. Our results show that the prolonged plasma residence time of SN-38/CSBC micelles as compared with free CPT-11 permit increased tumor accumulation and consequently, improved antitumor activity. The combined effects of SN-38/CSBC micelles with PDT were evaluated in an HT-29 human colon cancer xenograft model. Interesting, SN-38/CSBC-mediated PDT synergistically inhibited tumor growth, resulting in up to 60% complete regression of well-established tumors after 3 treatments. These treatments also decreased the microvessel density (MVD) and cell proliferation within the subcutaneous tumors. Therefore, this SN-38/CBSC delivery system has the potential to offer dual therapies for the synergistic combination of PDT and chemotherapy for the treatment of cancer. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/638361 | ISSN: | 01429612 | DOI: | 10.1016/j.biomaterials.2009.03.048 |
顯示於: | 醫學系 |
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