https://scholars.lib.ntu.edu.tw/handle/123456789/638875
標題: | Biomaterials use in Ex vivo Testing and Animal Model | 作者: | Shen, Chia Ning Huang, Wen Yen SUNG-JAN LIN NAI-CHEN CHENG MIN-HUEY CHEN Lee, I. Chi Li, Yi Chen Ethan |
公開日期: | 1-一月-2023 | 來源出版物: | Stem Cell-based Biosystems | 摘要: | This chapter introduces the evaluation methods from laboratory testing, ex vivo testing, animal models, and pre-clinical testing of biomaterials, stem cell-based system, and their derivate-relative products. During a pre-clinical testing process, developing new therapies for damaged tissues or diseases should be evaluated by using in vitro cell testing and in vivo animal studies. The ex vivo models bring hope to provide a 3D biomimetic environment to bridge the gap between in vitro cell testing and in vivo animal studies. Therefore, ex vivo testings enable offering a promising to provide more confident results in preclinical testing. Adipose-derived stem cells and induced pluripotent stem cells (iPSCs) are two stem cells that have been widely used in regenerative medicine field. iPSC-derived products intended for clinical use should be used in pre-clinical studies. Immunosuppressed or immunocompromised animals should be studied to prevent human cell rejection in animal studies. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/638875 | ISBN: | 9781003822684 | DOI: | 10.1201/9781003130048-9 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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