https://scholars.lib.ntu.edu.tw/handle/123456789/638909
標題: | Increased interleukin-1 beta levels in gingival crevicular fluid of Chinese periodontal patients | 作者: | Hou, L T CHEING-MEEI LIU Chang, W K |
公開日期: | 二月-1994 | 卷: | 93 | 期: | 2 | 來源出版物: | Journal of the Formosan Medical Association = Taiwan yi zhi | 摘要: | One hundred and twenty-four gingival crevicular fluid (GCF) samples were harvested from 13 healthy and 111 diseased gingival sites in 10 patients with periodontitis. The total amount and concentration of interleukin-1 beta (IL-1 beta) in each sample was measured by the enzyme-linked immunosorbent assay (ELISA) technique using an ELISA Kit specific for this cytokine. The IL-1 beta was undetectable in 23% of the GCF from clinically non-inflamed sites (three out of 13), while it could mostly be identified in diseased sites (109/111). The amount of IL-1 beta varied from 4.03 to 511.12 pg/site in diseased GCF samples. The average IL-1 beta amount from diseased sites was three-fold that from non-inflamed sites. Total IL-1 beta amount and the GCF volume were significantly increased with elevated gingival index (GI) score and deeper probing depth (PD). However, no significant difference of crevicular IL-1 beta concentration (pg/microL) could be found among groups with different clinical parameters. Our results indicate that IL-1 beta was present in the GCF of most clinically non-inflamed gingiva and almost all diseased pockets. The significant elevation of total IL-1 beta amount and GCF volume in diseased sulci suggests that it is closely associated with the severity of periodontal disease. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/638909 | ISSN: | 0929-6646 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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