https://scholars.lib.ntu.edu.tw/handle/123456789/639009
標題: | MicroRNAs and cataracts: Correlation among let-7 expression, age and the severity of lens opacity | 作者: | Peng, Chi Hsien Liu, Jorn Hon LIN-CHUNG WOUNG Lin, Tzu Jung Chiou, Shih Hwa Tseng, Po Chen Du, Wen Yuan Cheng, Cheng Kuo Hu, Chao Chien Chien, Ke Hung Chen, Shih Jen |
公開日期: | 1-五月-2012 | 卷: | 96 | 期: | 5 | 來源出版物: | British Journal of Ophthalmology | 摘要: | Background: Let-7 microRNA is an important regulator of cellular ageing and tissue senescence. The objective of this study is to evaluate the expression of let-7a/let-7b/ let-7c microRNAs in human age-related cataracts. Aim: To evaluate the correlation among the severity of lens opacity, the level of let-7a/let-7b/let-7c microRNA expression and patient age in the context of age-related cataracts. Methods: The authors evaluated the mRNA level of let- 7a/let-7b/let-7c microRNA in lens epithelia obtained from 174 eyes with age-related cataracts. The authors also recorded the patient age and the severity of lens opacity as classified according to the modified version of the Lens Opacities Classification System version III. Results: Let-7b microRNA expression was demonstrated to be positively associated with patient age (R=0.472; p<0.001). A positive correlation was also observed between higher N, C and P cataract scores and higher expression of let-7b microRNA in patients with agerelated cataracts (p<0.001). However, no significant correlation was observed between the let-7a and let-7c microRNA expression levels and either the severity of lens opacity or the patient age. Conclusion: These findings suggest that microRNAs play a role in age-related cataracts. A local let-7b microRNA increase may represent a risk factor in the formation of age-related cataracts. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639009 | ISSN: | 00071161 | DOI: | 10.1136/bjophthalmol-2011-300585 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。