https://scholars.lib.ntu.edu.tw/handle/123456789/639032
Title: | Celecoxib enhances radiosensitivity in medulloblastoma-derived CD133-positive cells | Authors: | Chen, Kuan-Hsuan Hsu, Chuan-Chih Song, Wen-Shin Huang, Chi-Shuan Tsai, Chia-Chen Kuo, Cheng-Deng Hsu, Han-Shui Tsai, Tung-Hu Tsai, Ching-Yao LIN-CHUNG WOUNG Chiou, Shih-Hwa Lu, Kai-Hsi Chen, Yi-Wei |
Keywords: | CD133 | Celecoxib | Daoy | Medulloblastoma | Radiosensitivity | Issue Date: | Nov-2010 | Journal Volume: | 26 | Journal Issue: | 11 | Source: | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery | Abstract: | Cyclooxygenase-2 (COX-2), the enzyme that converts arachidonic acid to prostaglandins, is overexpressed in a variety of tumors, including medulloblastoma (MB). CD133, a transmembrane glycoprotein, has been suggested as a marker for cancer stem cells in brain tumors. The aim of the present study was to investigate the role of celecoxib, a selective COX-2 inhibitor, in enhancing the effects of ionizing radiotherapy (IR) on medulloblastoma-derived CD133-positive cells (MB-CD133(+)). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639032 | ISSN: | 02567040 | DOI: | 10.1007/s00381-010-1190-2 |
Appears in Collections: | 醫學系 |
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