https://scholars.lib.ntu.edu.tw/handle/123456789/639468
標題: | Optimal inhaled oxygen and carbon dioxide concentrations for post-cardiac arrest cerebral reoxygenation and neurological recovery | 作者: | CHIH-HUNG WANG WEI-TIEN CHANG CHIEN-HUA HUANG MIN-SHAN TSAI Wang, Chan-Chi SHING-HWA LIU WEN-JONE CHEN |
關鍵字: | Anesthesiology; Cardiovascular medicine; Physiology | 公開日期: | 15-十二月-2023 | 出版社: | Elsevier Inc. | 卷: | 26 | 期: | 12 | 來源出版物: | iScience | 摘要: | Prolonged cerebral hypoperfusion after the return of spontaneous circulation (ROSC) from cardiac arrest (CA) may lead to poor neurological recovery. In a 7-min asphyxia-induced CA rat model, four combinations of inhaled oxygen (iO2) and carbon dioxide (iCO2) were administered for 150 min post-ROSC and compared in a randomized animal trial. At the end of administration, the partial pressure of brain tissue oxygenation (PbtO2) monitored in the hippocampal CA1 region returned to the baseline for the 88% iO2 [ΔPbtO2, median: -0.39 (interquartile range: 5.6) mmHg] and 50% iO2 [ΔpbtO2, -2.25 (10.9) mmHg] groups; in contrast, PbtO2 increased substantially in the 88% iO2+12% iCO2 [ΔpbtO2, 35.05 (16.0) mmHg] and 50% iO2+12% iCO2 [ΔpbtO2, 42.03 (31.7) mmHg] groups. Pairwise comparisons (post hoc Dunn's test) indicated the significant role of 12% iCO2 in augmenting PbtO2 during the intervention and improving neurological recovery at 24 h post-ROSC. Facilitating brain reoxygenation may improve post-CA neurological outcomes. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639468 | ISSN: | 25890042 | DOI: | 10.1016/j.isci.2023.108476 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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