https://scholars.lib.ntu.edu.tw/handle/123456789/639473
標題: | Delayed Collagen Production without Myofibroblast Formation Contributes to Reduced Scarring in Adult Skin Microwounds | 作者: | CHEN-HSIANG KUAN Tai, Kang-Yu Lu, Shao-Chi Wu, Yueh-Feng Wu, Pei-Shan Kwang, Nellie Wang, Wei-Hung Mai-Yi Fan, Sabrina Wang, Shiou-Han Chien, Hsiung-Fei HONG-SHIEE LAI Lin, Miao-Hsia Plikus, Maksim V Lin, Sung-Jan |
關鍵字: | Collagen; Inflammation; Microwounds; Myofibroblasts; Wound healing | 公開日期: | 29-十一月-2023 | 來源出版物: | The Journal of investigative dermatology | 摘要: | In adult mammals, wound healing predominantly follows a fibrotic pathway, culminating in scar formation. However, cutaneous microwounds generated through fractional photothermolysis, a modality that produces a constellation of microthermal zones, exhibit a markedly different healing trajectory. Our study delineates the cellular attributes of these microthermal zones, underscoring a temporally limited, subclinical inflammatory milieu concomitant with rapid re-epithelialization within 24 hours. This wound closure is facilitated by the activation of genes associated with keratinocyte migration and differentiation. In contrast to macrothermal wounds, which predominantly heal through a robust myofibroblast-mediated collagen deposition, microthermal zones are characterized by absence of wound contraction and feature delayed collagen remodeling, initiating 5-6 weeks after injury. This distinct wound healing is characterized by a rapid re-epithelialization process and a muted inflammatory response, which collectively serve to mitigate excessive myofibroblast activation. Furthermore, we identify an initial reparative phase characterized by a heterogeneous extracellular matrix protein composition, which precedes the delayed collagen remodeling. These findings extend our understanding of cutaneous wound healing and may have significant implications for the optimization of therapeutic strategies aimed at mitigating scar formation. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639473 | ISSN: | 0022202X | DOI: | 10.1016/j.jid.2023.10.029 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。