https://scholars.lib.ntu.edu.tw/handle/123456789/639474
標題: | Assembly of Interfacial Polyelectrolyte Complexation Fiber Bundles with Mineralization Gradient for Physiologically-inspired Ligament Regeneration | 作者: | Wang, Tzu-Wei Liu, Yu-Chung Chen, Shih-Heng CHEN-HSIANG KUAN Chen, Shih-Shien Huang, Wei-Yuan Chen, Hao-Xuan Wu, Hsi-Chin |
關鍵字: | bone-ligament interface; hierarchical structure; interfacial polyelectrolyte complexation; ligament tissue engineering; mineralization gradient | 公開日期: | 1-十一月-2023 | 來源出版物: | Research Square | 摘要: | Current synthetic grafts for ligament rupture repair often fail to integrate well with the surrounding biological tissue, leading to complications such as graft wear, fatigue, and subsequent re-rupture. To address this medical challenge, this study aims at advancing the development of a biological ligament through the integration of physiologically-inspired principles and tissue engineering strategies. In this study, we utilize interfacial polyelectrolyte complexation spinning technique, along with a custom-designed collection system, to fabricate a hierarchical scaffold mimicking native ligament structure. To emulate the bone-ligament interface and alleviate stress concentration, a hydroxyapatite mineral gradient is strategically introduced near both ends of the scaffold to enhance interface integration and diminish the risk of avulsion rupture. Biomimetic viscoelasticity is successfully displayed to provide similar mechanical support to native ligamentous tissue under physiological conditions. By introducing the connective tissue growth factor and conducting mesenchymal stem cells transplantation, we significantly amplify the regenerative potential of the synthetic ligament. This pioneering study offers a multifaceted solution combining biomimetic materials, regenerative therapies, and advanced techniques to potentially transform ligament rupture treatment. © 2023, CC BY. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639474 | DOI: | 10.21203/rs.3.rs-3455055/v1 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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