Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study
Journal
PloS one
Journal Volume
10
Journal Issue
10
Date Issued
2015
Author(s)
Murray, Daniel D
Suzuki, Kazuo
Law, Matthew
Trebicka, Jonel
Neuhaus, Jacquie
Wentworth, Deborah
Johnson, Margaret
Vjecha, Michael J
Kelleher, Anthony D
Emery, Sean
INSIGHT ESPRIT and SMART Study Groups
Abstract
The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals.
SDGs
Type
journal article