A novel computer-assisted tool for 3D imaging of programmed death-ligand 1 expression in immunofluorescence-stained and optically cleared breast cancer specimens
Journal
BMC cancer
Journal Volume
24
Journal Volume
24
Journal Issue
1
Journal Issue
1
Start Page
論文號碼 121
Date Issued
2024-12-01
Author(s)
Lee, Yi-Hsuan
Huang, Chung-Yen
Hsieh, Yu-Han
Yang, Chia-Hung
Hung, Yu-Ling
Chen, Yung-An
Lin, Yu-Chieh
Wang, Ming-Yang
Lin, Yen-Yin
Abstract
Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) are the two most common immune checkpoints targeted in triple-negative breast cancer (BC). Refining patient selection for immunotherapy is non-trivial and finding an appropriate digital pathology framework for spatial analysis of theranostic biomarkers for PD-1/PD-L1 inhibitors remains an unmet clinical need.
Subjects
Breast cancer; Immunofluorescence staining; Optical clearing; Programmed death-ligand 1; Three-dimensional imaging
Type
journal article