https://scholars.lib.ntu.edu.tw/handle/123456789/639680
標題: | Performance evaluation of the cobas SARS-CoV-2 Duo, a novel qualitative and quantitative assay, for the detection of SARS-CoV-2 RNA | 作者: | Su, Yang-Di Lai, Chih-Cheng Lin, Tsai-Hsiu Chen, Wei-Cheng PO-REN HSUEH |
關鍵字: | COVID-19; SARS-CoV-2; cobas SARS-CoV-2 Duo; qualitative; quantitative | 公開日期: | 12-十二月-2023 | 卷: | 11 | 期: | 6 | 來源出版物: | Microbiology spectrum | 摘要: | Quantitative SARS-CoV-2 tests for viral load are necessary to guide patient treatment, as well as to determine infection control measures and policies. Although the real-time RT-PCR assays can report the Ct value to estimate the viral load, there are several serious concerns regarding the use of Ct values. Importantly, Ct values can vary significantly among between- and within-run methods. The diagnostic performance of the cobas SARS-CoV-2 Duo is appropriate. It is a precise, accurate, and sensitive method for the detection of SARS-CoV-2 RNA and is comparable to two qualitative assays (the cobas SARS-CoV-2 and the Liat cobas SARS-CoV-2 and Inf A/B). In contrast, using the Ct value to estimate viral load is not reliable, and utilization of a quantitative detection test, such as the cobas SARS-CoV-2 Duo, to accurately measure the viral load is needed. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639680 | ISSN: | 2165-0497 | DOI: | 10.1128/spectrum.01369-23 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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