https://scholars.lib.ntu.edu.tw/handle/123456789/639684
標題: | Use of Multiple Doses of Intravenous Infusion of Umbilical Cord-Mesenchymal Stem Cells for the Treatment of Adult Patients with Severe COVID-19-Related Acute Respiratory Distress Syndrome: Literature Review | 作者: | PO-REN HSUEH Ho, Sung-Jung Hsieh, Po-Chuen Liu, I-Min Jean, Shio-Shin |
公開日期: | 2023 | 卷: | 2023 | 來源出版物: | Stem cells international | 摘要: | Acute respiratory distress syndrome (ARDS) is a critical complication in severe COVID-19 patients. The intravenous infusion (IVF) of umbilical cord- (UC-) mesenchymal stem cells (MSCs), validated to substantially reduce the release of several inflammatory cytokines in vivo, was also shown to exhibit benefits in improving hypoxemia among severe COVID-19 patients. A single dose of IVF-UC-MSCs therapy for severe COVID-19 patients was shown to alleviate the initial ARDS severity, but have 50%-67% case-fatality rates. In Taiwan, few adult patients with severe COVID-19-induced ARDS receiving compassionate adjuvant treatment consisting of either a single dose (1-10 × 106 cells/kg body weight (kg BW)) or three doses (5 × 106 cells/kg BW in each dose) of IVF-UC-MSCs had good outcomes. However, the optimal dosage and rounds of IVF-UC-MSCs administration for the treatment of severe COVID-19 patients with ARDS are undetermined. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639684 | ISSN: | 1687-966X | DOI: | 10.1155/2023/7179592 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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