https://scholars.lib.ntu.edu.tw/handle/123456789/639761
標題: | Occurrence and characteristics of extended-spectrum-β-lactamase- and pAmpC-producing Klebsiella pneumoniae isolated from companion animals with urinary tract infections | 作者: | Lee, Megan Min Yi Kuan, Nan Ling Li, Zhi Yi KUANG-SHENG YEH |
公開日期: | 1-一月-2024 | 卷: | 19 | 期: | 1 January | 來源出版物: | PLoS ONE | 摘要: | This study examined 70 Klebsiella pneumoniae isolates derived from companion animals with urinary tract infections in Taiwan. Overall, 81% (57/70) of the isolates carried extendedspectrum β-lactamase (ESBL) and/or plasmid-encoded AmpC (pAmpC) genes. ESBL genes were detected in 19 samples, with blaCTX-M-1, blaCTX-M-9, and blaSHV being the predominant groups. pAmpC genes were detected in 56 isolates, with blaCIT and blaDHA being the predominant groups. Multilocus sequence typing revealed that sequence types (ST)11, ST15, and ST655 were prevalent. wabG, uge, entB, mrkD, and fimH were identified as primary virulence genes. Two isolates demonstrated a hypermucoviscosity phenotype in the string test. Antimicrobial susceptibility testing exhibited high resistance to β-lactams and fluoroquinolones in ESBL-positive isolates but low resistance to aminoglycosides, sulfonamides, and carbapenems. Isolates carrying pAmpC genes exhibited resistance to penicillin-class β-lactams. These findings provide valuable insights into the role of K. pneumoniae in the context of the concept of One Health. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182553356&doi=10.1371%2fjournal.pone.0296709&partnerID=40&md5=826baf48e9d872e82fe8519291e3e8ea https://scholars.lib.ntu.edu.tw/handle/123456789/639761 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0296709 |
顯示於: | 獸醫學系 |
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