https://scholars.lib.ntu.edu.tw/handle/123456789/639783
標題: | Suppressing c-FOS expression by G-quadruplex ligands inhibits osimertinib-resistant non-small cell lung cancer | 作者: | Lu, Kai Wang, Hsin-Chiao Tu, Yi-Chen Chang, Cheng-Chung PEI-JEN LOU Chang, Ta-Chau JING-JER LIN |
公開日期: | 8-十一月-2023 | 卷: | 115 | 期: | 11 | 來源出版物: | Journal of the National Cancer Institute | 摘要: | Osimertinib is the first-line therapy for patients with non-small cell lung cancer harboring epidermal growth factor receptor-activating alterations. Although osimertinib has been shown to elicit profound patient responses, cancer cells frequently develop additional alterations that sustain their proliferation capacity. This acquired resistance represents a substantial hurdle in precision medicine for patients with lung cancer. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639783 | ISSN: | 00278874 | DOI: | 10.1093/jnci/djad142 |
顯示於: | 生物化學暨分子生物學科研究所 |
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