https://scholars.lib.ntu.edu.tw/handle/123456789/639835
標題: | Minimum inhibitory concentrations of antifungals against invasive isolates of Cryptococcus species worldwide: Global antifungal antimicrobial testing leadership and surveillance program, 2010-2020 | 作者: | Jean, Shio-Shin Liu, Chia-Ying YU-TSUNG HUANG Ko, Wen-Chien Ho, Mao-Wang Liu, I-Min Hsieh, Po-Chuen PO-REN HSUEH |
關鍵字: | Amphotericin B; Cryptococcus species; Epidemiological cutoff value; Fluconazole; Voriconazole | 公開日期: | 18-一月-2024 | 卷: | 63 | 期: | 3 | 來源出版物: | International journal of antimicrobial agents | 摘要: | This study examined the geographic distribution of minimum inhibitory concentrations (MICs) of antifungals against Cryptococcus isolates. Data were collected on the MICs of specific antifungals (amphotericin B, 5-flucytosine, fluconazole, voriconazole, posaconazole, and isavuconazole) against various Cryptococcus species for the period 2010 to 2020 from the Antimicrobial Testing Leadership and Surveillance database. Cryptococcus isolates were collected from samples of blood and cerebrospinal fluid (CSF) from patients hospitalized in different regions worldwide. We applied the epidemiological cutoff values (ECVs) of antifungals against various Cryptococcus species to distinguish wild-type (WT) from non-WT Cryptococcus isolates. A total of 395 isolates of Cryptococcus species cultured from blood (n = 201) or CSF (n = 194) were analyzed. C. grubii (n = 270), C. neoformans (n = 111), and C. gattii (n = 11) were the three predominant species causing bloodstream infections (BSI) or meningitis/meningoencephalitis (MME). The proportion of MICs above the ECV (1 mg/L) for amphotericin B among C. neoformans isolates was significantly lower than that among C. gattii isolates (MICs >0.5 mg/L; P < 0.001), as evaluated using the chi-square test. For most isolates of the three predominant Cryptococcus species, the MICs of new triazoles were ≤0.25 mg/L. The MICs of fluconazole and amphotericin B in the BSI/MME-causing Cryptococcus isolates collected from patients hospitalized in the Asia-Western Pacific region and Europe were significantly lower (i.e., the distributions were more leftward) than those in North America and Latin America. Ongoing monitoring of MIC data for important antifungals against cryptococcosis is crucial. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639835 | ISSN: | 09248579 | DOI: | 10.1016/j.ijantimicag.2024.107090 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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