https://scholars.lib.ntu.edu.tw/handle/123456789/639921
標題: | CD44s and CD44v8-10 isoforms confer acquired resistance to osimertinib by activating the ErbB3/STAT3 signaling pathway | 作者: | Liu, Yi-Nan Tsai, Meng-Feng SHANG-GIN WU Chang, Tzu-Hua JIN-YUAN SHIH |
關鍵字: | Acquired resistance; CD44 isoform; Lung cancer; Osimertinib | 公開日期: | 1-一月-2024 | 卷: | 336 | 來源出版物: | Life sciences | 摘要: | Although epidermal growth factor receptor (EGFR)-mutant lung cancers respond well to osimertinib, acquired resistance to osimertinib eventually develops through EGFR-dependent and EGFR-independent resistance mechanisms. CD44 splicing variants are widely expressed in lung cancer tissues. However, it remains unclear whether specific splicing variants are involved in acquired resistance to osimertinib. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639921 | ISSN: | 00243205 | DOI: | 10.1016/j.lfs.2023.122345 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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