https://scholars.lib.ntu.edu.tw/handle/123456789/640260
標題: | The timing of intravenous antibiotics and clinical outcomes of Mycobacterium abscessus complex lung diseases | 作者: | Pang, A. H. SHU-WEN LIN Yang, J. H. Wang, P. H. Pan, S. W. Wei, Y. F. CHUNG-YU CHEN Lee, H. S. Wu, T. S. Chang, C. H. CHIN-CHUNG SHU |
公開日期: | 1-二月-2024 | 卷: | 28 | 期: | 2 | 起(迄)頁: | 4 | 來源出版物: | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease | 摘要: | BACKGROUND: The importance of early intravenous (IV) antibiotic use for Mycobacterium abscessus complex lung diseases (MABC-LD) treatment remains unknown. METHODS: A retrospective multi-centre observational study was conducted in Taiwan. Patients who were diagnosed with and received treatment for MABC-LD from January 2007 to April 2021 were included. Treatment outcome was defined as modified microbiological cure of MABC-LD.RESULTS: Of the 89 enrolled patients, 34 (38.2%) received IV antibiotics as part of the treatment regimen. The median time to IV initiation was 1 day (IQR 1???49); 24 (70.6%) of these patients received IV agents within 4 weeks, defined as early-use. Forty-two (47.2%) patients achieved modified microbiological cure. In the multivariable logistic analysis, early IV antibiotic use was an independent factor associated with modified microbiological cure (aOR 5.32, 95% CI 1.66???17.00), whereas high radiological score (aOR 0.86, 95% CI 0.73???1.00) demonstrated negative association.CONCLUSIONS: In the present study, early use of effective IV antibiotic was prescribed in a low percentage (27%) for MABC-LD. By contrast, early IV antibiotic use was correlated with higher microbiological cure than were late or non-use. Future larger and prospective studies are needed to validate the association. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/640260 | ISSN: | 1027-3719 | DOI: | 10.5588/ijtld.23.0086 |
顯示於: | 藥學系 |
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