https://scholars.lib.ntu.edu.tw/handle/123456789/640345
標題: | Effectiveness of a reduced dose of efavirenz plus 2 NRTIs as maintenance antiretroviral therapy with the guidance of therapeutic drug monitoring | 作者: | Yang, Shang-Ping Liu, Wen-Chun Lee, Kuan-Yeh Wu, Bing-Ru Su, Yi-Ching Wu, Pei-Ying Zhang, Jun-Yu Luo, Yu-Zhen Sun, Hsin-Yun Chang, Sui-Yuan SHU-WEN LIN Hung, Chien-Ching |
公開日期: | 2-十一月-2014 | 卷: | 17 | 期: | 4 (Suppl 3) | 起(迄)頁: | 19524 | 來源出版物: | Journal of the International AIDS Society | 摘要: | Wide inter-patient variation of plasma efavirenz (EFV) concentrations has been observed, and a substantial proportion of HIV-positive patients may have unnecessarily higher plasma EFV concentrations than recommended while receiving EFV-containing combination antiretroviral therapy (cART) at the currently recommended daily dose of 600 mg. A lower daily dose (400 mg) of EFV has recently been demonstrated to be as efficacious as the recommended 600 mg when combined with tenofovir/mtricitabine in a multinational clinical trial, with a lower incidence of adverse effects. We aimed to use a therapeutic drug monitoring (TDM)-guided strategy to optimize the EFV dose in HIV-positive Taiwanese patients. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/640345 | ISSN: | 1758-2652 | DOI: | 10.7448/IAS.17.4.19524 |
顯示於: | 藥學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。