https://scholars.lib.ntu.edu.tw/handle/123456789/640436
標題: | Analysis across Taiwan Biobank, Biobank Japan, and UK Biobank identifies hundreds of novel loci for 36 quantitative traits | 作者: | Chen, Chia-Yen Chen, Tzu-Ting YEN-CHEN ANNE FENG Yu, Mingrui Lin, Shu-Chin Longchamps, Ryan J Wang, Shi-Heng Hsu, Yi-Hsiang Yang, Hwai-I PO-HSIU KUO Daly, Mark J Chen, Wei J Huang, Hailiang Ge, Tian Lin, Yen-Feng |
關鍵字: | Taiwan Biobank; cross-ancestry GWAS; multi-polygenic score prediction; quantitative traits | 公開日期: | 13-十二月-2023 | 出版社: | Cell Press | 卷: | 3 | 期: | 12 | 來源出版物: | Cell Genomics | 摘要: | Genome-wide association studies (GWASs) have identified tens of thousands of genetic loci associated with human complex traits. However, the majority of GWASs were conducted in individuals of European ancestries. Failure to capture global genetic diversity has limited genomic discovery and has impeded equitable delivery of genomic knowledge to diverse populations. Here we report findings from 102,900 individuals across 36 human quantitative traits in the Taiwan Biobank (TWB), a major biobank effort that broadens the population diversity of genetic studies in East Asia. We identified 968 novel genetic loci, pinpointed novel causal variants through statistical fine-mapping, compared the genetic architecture across TWB, Biobank Japan, and UK Biobank, and evaluated the utility of cross-phenotype, cross-population polygenic risk scores in disease risk prediction. These results demonstrated the potential to advance discovery through diversifying GWAS populations and provided insights into the common genetic basis of human complex traits in East Asia. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/640436 | ISSN: | 2666979X | DOI: | 10.1016/j.xgen.2023.100436 |
顯示於: | 流行病學與預防醫學研究所 |
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