標題: | Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study |
作者: | Ou, Anna H Rosenthal, Sara B Adli, Mazda Akiyama, Kazufumi Akula, Nirmala Alda, Martin Amare, Azmeraw T Ardau, Raffaella Arias, Bárbara Aubry, Jean-Michel Backlund, Lena Bauer, Michael Baune, Bernhard T Bellivier, Frank Benabarre, Antonio Bengesser, Susanne Bhattacharjee, Abesh Kumar Biernacka, Joanna M Cervantes, Pablo Chen, Guo-Bo Chen, Hsi-Chung Chillotti, Caterina Cichon, Sven Clark, Scott R Colom, Francesc Cousins, David A Cruceanu, Cristiana Czerski, Piotr M Dantas, Clarissa R Dayer, Alexandre Del Zompo, Maria Degenhardt, Franziska DePaulo, J Raymond Étain, Bruno Falkai, Peter Fellendorf, Frederike Tabea Ferensztajn-Rochowiak, Ewa Forstner, Andreas J Frisén, Louise Frye, Mark A Fullerton, Janice M Gard, Sébastien Garnham, Julie S Goes, Fernando S Grigoroiu-Serbanescu, Maria Grof, Paul Gruber, Oliver Hashimoto, Ryota Hauser, Joanna Heilbronner, Urs Herms, Stefan Hoffmann, Per Hofmann, Andrea Hou, Liping Jamain, Stephane Jiménez, Esther Kahn, Jean-Pierre Kassem, Layla Kato, Tadafumi Kittel-Schneider, Sarah König, Barbara PO-HSIU KUO Kusumi, Ichiro Lackner, Nina Laje, Gonzalo Landén, Mikael Lavebratt, Catharina Leboyer, Marion Leckband, Susan G Jaramillo, Carlos A López MacQueen, Glenda Maj, Mario Manchia, Mirko Marie-Claire, Cynthia Martinsson, Lina Mattheisen, Manuel McCarthy, Michael J McElroy, Susan L McMahon, Francis J Mitchell, Philip B Mitjans, Marina Mondimore, Francis M Monteleone, Palmiero Nievergelt, Caroline M Nöthen, Markus M Novák, Tomas Ösby, Urban Ozaki, Norio Papiol, Sergi Perlis, Roy H Pisanu, Claudia Potash, James B Pfennig, Andrea Reich-Erkelenz, Daniela Reif, Andreas Reininghaus, Eva Z Rietschel, Marcella Rouleau, Guy A Rybakowski, Janusz K Schalling, Martin Schofield, Peter R Schubert, K Oliver Schulze, Thomas G Schweizer, Barbara W Seemüller, Florian Severino, Giovanni Shekhtman, Tatyana Shilling, Paul D Shimoda, Kazutaka Simhandl, Christian Slaney, Claire M Squassina, Alessio Stamm, Thomas Stopkova, Pavla Tighe, Sarah K Tortorella, Alfonso Turecki, Gustavo Vieta, Eduard Volkert, Julia Witt, Stephanie Wray, Naomi R Wright, Adam Young, L Trevor Zandi, Peter P Kelsoe, John R |
公開日期: | 23-二月-2024 |
出版社: | Springer Nature |
卷: | 14 |
期: | 1 |
來源出版物: | Translational Psychiatry |
摘要: | Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/640440 |
ISSN: | 2158-3188 |
DOI: | 10.1038/s41398-024-02811-4 |
顯示於: | 流行病學與預防醫學研究所
|