https://scholars.lib.ntu.edu.tw/handle/123456789/640682
標題: | Discovery of new dibenzodiazepine derivatives as antibacterials against intracellular bacteria | 作者: | Chen, Ling-Han Lin, Man-Yi Lin, Hsueh-Chun Yang, Fan-Wei Liao, Hsiao-Wei Shiau, Chung-Wai HAO-CHIEH CHIU Su, Jung-Chen |
公開日期: | 25-一月-2024 | 卷: | 15 | 期: | 1 | 來源出版物: | RSC medicinal chemistry | 摘要: | The emergence and spread of multidrug-resistant bacteria underscore the critical need for novel antibacterial interventions. In our screening of 12 synthesized thienobenzodiazepines, pyridobenzodiazepines, and dibenzodiazepines, we successfully identified a small molecule compound SW33. Notably, SW33 demonstrated potent inhibitory activity against intracellular multidrug-resistant and fluoroquinolone-resistant strains of S. typhimurium in both macrophages and epithelial cells. Furthermore, SW33 was also effective against intramacrophagic Salmonella typhi, Yersinia enterocolitica, and Listeria monocytogenes. These significant findings suggest that SW33 possesses broad-spectrum activity against intracellular bacteria. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/640682 | ISSN: | 26328682 | DOI: | 10.1039/d3md00418j |
顯示於: | 醫學檢驗暨生物技術學系 |
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