https://scholars.lib.ntu.edu.tw/handle/123456789/640718
標題: | Recapitulating the immune system of hemophilia A patients with inhibitors using immunodeficient mice | 作者: | SHENG-CHIEH CHOU Yen, Ching-Tzu Yang, Yung-Li Chen, Shu-Huey Wang, Jiaan-Der Fan, Meng-Ni Chen, Li-Fu Yu, I-Shing Tsai, Dong-Yan Lin, Kuo-I Tao, Mi-Hua JUI-CHING WU SHU-WHA LIN |
關鍵字: | FVIII inhibitor; Hemophilia A; Humanized hemophilia NSG mice | 公開日期: | 三月-2024 | 卷: | 235 | 來源出版物: | Thrombosis research | 摘要: | Treating hemophilia A patients who develop inhibitors remains a clinical challenge. A mouse model of hemophilia A can be used to test the efficacy of strategies for inhibitor suppression, but the differences in the immune systems of mice and humans limit its utility. To address this shortcoming, we established a humanized NOD/SCID-IL2rγnull hemophilia A (hu-NSG-HA) mouse model with a severely deficient mouse immune system presenting a patient's adapted immune cells. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/640718 | ISSN: | 00493848 | DOI: | 10.1016/j.thromres.2024.01.019 |
顯示於: | 醫學檢驗暨生物技術學系 |
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