https://scholars.lib.ntu.edu.tw/handle/123456789/640747
標題: | The predictors of long-term outcomes after targeted therapy for primary Aldosteronism | 作者: | Chen, Ying-Ying Huang, Shun-Chen CHIEN-TING PAN Peng, Kang-Yung Lin, Liang-Yu CHIEH-KAI CHAN CHIA-TUNG SHUN |
關鍵字: | Aldosterone-producing adenoma; Histopathological classification; KCNJ5 mutation; Primary aldosteronism surgical outcome (PASO); Scoring system | 公開日期: | 三月-2024 | 卷: | 123 Suppl 2 | 來源出版物: | Journal of the Formosan Medical Association = Taiwan yi zhi | 摘要: | Unilateral primary aldosteronism is thought to be a surgically curable disease, and unilateral adrenalectomy is the mainstay treatment. The Primary Aldosteronism Surgical Outcome (PASO) consensus was developed to assess clinical and biochemical outcomes to standardize the classification of surgical outcomes. However, fewer than half of patients are cured of hypertension after adrenalectomy; therefore, preoperative patient counseling and evaluation might be necessary. Moreover, current studies show that genetic mutations and histopathology classification are associated with the treatment outcome. The Task Force of Taiwan PA recommends using a specific scoring system, including the PASO score and nomogram-based preoperative score, to predict the clinical outcome before adrenalectomy. Herein, we discuss the associations of current histopathological classification and specific somatic gene mutations with clinical outcomes after surgery. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/640747 | ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2023.11.005 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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