https://scholars.lib.ntu.edu.tw/handle/123456789/640818
標題: | Integrated analysis identifies GABRB3 as a biomarker in prostate cancer | 作者: | Chen, Jun-Yan Chang, Chi-Fen Huang, Shu-Pin CHAO-YUAN HUANG Yu, Chia-Cheng Lin, Victor C Geng, Jiun-Hung Li, Chia-Yang Lu, Te-Ling Bao, Bo-Ying |
關鍵字: | GABRB3; Gene set enrichment analysis; PI3K/AKT pathway; Prostate cancer; Survival | 公開日期: | 29-一月-2024 | 卷: | 17 | 期: | 1 | 來源出版物: | BMC medical genomics | 摘要: | Treatment failure following androgen deprivation therapy (ADT) presents a significant challenge in the management of advanced prostate cancer. Thus, understanding the genetic factors influencing this process could facilitate the development of personalized treatments and innovative therapeutic strategies. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a pivotal role in controlling cell growth and tumorigenesis. We hypothesized that genetic variants within this pathway may affect the clinical outcomes of patients undergoing ADT for prostate cancer. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/640818 | ISSN: | 1755-8794 | DOI: | 10.1186/s12920-024-01816-8 |
顯示於: | 醫學系 |
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