https://scholars.lib.ntu.edu.tw/handle/123456789/641092
標題: | Shared genetic architectures of educational attainment in East Asian and European populations | 作者: | Chen, Tzu-Ting Kim, Jaeyoung Lam, Max Chuang, Yi-Fang Chiu, Yen-Ling Lin, Shu-Chin Jung, Sang-Hyuk Kim, Beomsu Kim, Soyeon Cho, Chamlee Shim, Injeong Park, Sanghyeon Ahn, Yeeun Okbay, Aysu Jang, Hyemin Kim, Hee Jin Seo, Sang Won Park, Woong-Yang Ge, Tian Huang, Hailiang YEN-CHEN ANNE FENG Lin, Yen-Feng Myung, Woojae Chen, Chia-Yen Won, Hong-Hee |
公開日期: | 5-一月-2024 | 來源出版物: | Nature Human Behaviour | 摘要: | Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive ability, is associated with various health and social outcomes. Previous genome-wide association studies (GWASs) on EduYears have been focused on samples of European (EUR) genetic ancestries. Here we present the first large-scale GWAS of EduYears in people of East Asian (EAS) ancestry (n = 176,400) and conduct a cross-ancestry meta-analysis with EduYears GWAS in people of EUR ancestry (n = 766,345). EduYears showed a high genetic correlation and power-adjusted transferability ratio between EAS and EUR. We also found similar functional enrichment, gene expression enrichment and cross-trait genetic correlations between two populations. Cross-ancestry fine-mapping identified refined credible sets with a higher posterior inclusion probability than single population fine-mapping. Polygenic prediction analysis in four independent EAS and EUR cohorts demonstrated transferability between populations. Our study supports the need for further research on diverse ancestries to increase our understanding of the genetic basis of educational attainment. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641092 | ISSN: | 2397-3374 | DOI: | 10.1038/s41562-023-01781-9 |
顯示於: | 流行病學與預防醫學研究所 |
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