https://scholars.lib.ntu.edu.tw/handle/123456789/641126
標題: | Efficacy and Mechanism of the Action of Live and Heat-Killed Bacillus coagulans BC198 as Potential Probiotic in Ameliorating Dextran Sulfate Sodium-Induced Colitis in Mice | 作者: | Koh, Yen Chun Chang, Ya Chu Lin, Wei Sheng Leung, Siu Yi Chen, Wei-Jen Wu, Shiuan Huei Wei, Yu Shan Gung, Chiau Ling Chou, Ya Chun MIN-HSIUNG PAN |
公開日期: | 5-三月-2024 | 卷: | 9 | 期: | 9 | 來源出版物: | ACS Omega | 摘要: | Inflammatory bowel disease alters the gut microbiota, causes defects in mucosal barrier function, and leads to dysregulation of the immune response to microbial stimulation. This study investigated and compared the efficacy of a candidate probiotic strain, Bacillus coagulans BC198, and its heat-killed form in treating dextran sulfate sodium-induced colitis. Both live and heat-killed B. coagulans BC198 increased gut barrier-associated protein expression, reduced neutrophil and M1 macrophage infiltration of colon tissue, and corrected gut microbial dysbiosis induced by colitis. However, only live B. coagulans BC198 could alleviate the general symptoms of colitis, prevent colon shortening, and suppress inflammation and tissue damage. At the molecular level, live B. coagulans BC198 was able to inhibit Th17 cells while promoting Treg cells in mice with colitis, reduce pro-inflammatory MCP-1 production, and increase anti-inflammatory IL-10 expression in the colonic mucosa. The live form of B. coagulans BC198 functioned more effectively than the heat-killed form in ameliorating colitis by enhancing the anti-inflammatory response and promoting Treg cell accumulation in the colon. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641126 | ISSN: | 2470-1343 2470-1343 |
DOI: | 10.1021/acsomega.3c07529 |
顯示於: | 食品科技研究所 |
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