Large-scale synthesis of per-O-acetylated saccharides and their sequential transformation to glycosyl bromides and thioglycosides
Journal
Journal of Carbohydrate Chemistry
Journal Volume
25
Journal Issue
4
Pages
303
Date Issued
2006-06-01
Author(s)
Abstract
This work describes a large-scale synthesis of per- O -acetylated mono- and disaccharides using a stoichiometric amount of acetic anhydride in the presence of LiClO 4 under solvent-free conditions. The peracetylated saccharides underwent subsequent anomeric bromination and thioglycosidation in one-pot to yield synthetically valuable building blocks. Copyright © Taylor & Francis Group, LLC.
Subjects
Acetylation | Glycosyl bromides | LiClO 4 | One-pot synthesis | Thioglycosides
Type
journal article