https://scholars.lib.ntu.edu.tw/handle/123456789/641371
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Ho, Ping-Chen | en_US |
dc.contributor.author | Hsiao, Fu-Yun | en_US |
dc.contributor.author | Chiu, Shi-Hong | en_US |
dc.contributor.author | Lee, Syun-Ruei | en_US |
dc.contributor.author | HAU-JIE YAU | en_US |
dc.date.accessioned | 2024-03-26T07:55:05Z | - |
dc.date.available | 2024-03-26T07:55:05Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 08926638 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/641371 | - |
dc.description.abstract | Recent studies have shown that the non-DA neurons in the ventral tegmental area (VTA) and substantia nigra (SN) not only modulate motivational behaviors but also regulate defensive behaviors. While zona incerta (ZI) is a threat-responsive substrate and receives innervations from the ventral midbrain, the function of the ventral midbrain-to-ZI connection remains poorly defined. Here, we demonstrate that the ZI receives heterogenous innervations from the ventral midbrain. By utilizing a retrograde AAV preferentially labeling non-DA neurons in the ventral midbrain, we found that ZI-projecting non-DA cells in the ventral midbrain are activated by restraint stress. We focused on the SN and found that SN-to-ZI GABAergic input is engaged by a predatory odor. Sustained pan-neuronal SN-to-ZI activation results in aversion and enhances defensive behaviors, likely through a disinhibition mechanism to recruit downstream brain regions that regulate defensive behaviors. Collectively, our results reveal a novel role of nigroincertal projection in mediating negative valence and regulating defensive behaviors. | en_US |
dc.language.iso | en | en_US |
dc.publisher | John Wiley and Sons Inc | en_US |
dc.relation.ispartof | FASEB Journal | en_US |
dc.subject | defensive behavior; stress; substantia nigra; ventral tegmental area; zona increta | en_US |
dc.title | A nigroincertal projection mediates aversion and enhances coping responses to potential threat | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1096/fj.202201989RR | - |
dc.identifier.pmid | 37983662 | - |
dc.identifier.scopus | 2-s2.0-85177476854 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85177476854 | - |
dc.relation.journalvolume | 37 | en_US |
dc.relation.journalissue | 12 | en_US |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.orcid | 0000-0001-7454-7971 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 腦與心智科學研究所 |
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