https://scholars.lib.ntu.edu.tw/handle/123456789/641371
Title: | A nigroincertal projection mediates aversion and enhances coping responses to potential threat | Authors: | Ho, Ping-Chen Hsiao, Fu-Yun Chiu, Shi-Hong Lee, Syun-Ruei HAU-JIE YAU |
Keywords: | defensive behavior; stress; substantia nigra; ventral tegmental area; zona increta | Issue Date: | Dec-2023 | Publisher: | John Wiley and Sons Inc | Journal Volume: | 37 | Journal Issue: | 12 | Source: | FASEB Journal | Abstract: | Recent studies have shown that the non-DA neurons in the ventral tegmental area (VTA) and substantia nigra (SN) not only modulate motivational behaviors but also regulate defensive behaviors. While zona incerta (ZI) is a threat-responsive substrate and receives innervations from the ventral midbrain, the function of the ventral midbrain-to-ZI connection remains poorly defined. Here, we demonstrate that the ZI receives heterogenous innervations from the ventral midbrain. By utilizing a retrograde AAV preferentially labeling non-DA neurons in the ventral midbrain, we found that ZI-projecting non-DA cells in the ventral midbrain are activated by restraint stress. We focused on the SN and found that SN-to-ZI GABAergic input is engaged by a predatory odor. Sustained pan-neuronal SN-to-ZI activation results in aversion and enhances defensive behaviors, likely through a disinhibition mechanism to recruit downstream brain regions that regulate defensive behaviors. Collectively, our results reveal a novel role of nigroincertal projection in mediating negative valence and regulating defensive behaviors. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641371 | ISSN: | 08926638 | DOI: | 10.1096/fj.202201989RR |
Appears in Collections: | 腦與心智科學研究所 |
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