https://scholars.lib.ntu.edu.tw/handle/123456789/641449
標題: | Streamlining regular liquid chromatography with MALDI-TOF MS and NMR spectroscopy using automatic full-contact splitless spotting interface and flash-tap fractioning collection | 作者: | Truong, Chi-Minh Jair, Yung-Cheng Chen, Hong-Po Chen, Wei-Chih Liu, Yi-Hsin Chen, Pin-Chuan PAI-SHAN CHEN |
關鍵字: | Automation; Fractioning and spotting; Liquid chromatography; Matrix-assisted laser desorption/ionization-time of flight-mass spectrometry; Nuclear magnetic resonance spectroscopy | 公開日期: | 15-四月-2024 | 出版社: | Elsevier B.V. | 卷: | 1298 | 來源出版物: | Analytica Chimica Acta | 摘要: | High-resolution matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) and nuclear magnetic resonance (NMR) spectroscopy are powerful tools to identify unknown psychoactive substances. However, in complex matrices, trace levels of unknown substances usually require additional fractionation and concentration. Specialized liquid chromatography systems are necessary for both techniques. The small flow rate of nano LC, typically paired with MALDI-TOF MS, often results in prolonged fractionation times. Conversely, the larger flow rate of semi-preparative LC, used for NMR analysis, can be time-consuming and labor-intensive when concentrating samples. To address these issues, we developed an integrated automatic system that integrated to regular LC. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641449 | ISSN: | 00032670 | DOI: | 10.1016/j.aca.2024.342401 |
顯示於: | 毒理學研究所 |
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