https://scholars.lib.ntu.edu.tw/handle/123456789/641491
標題: | Role of Perampanel in the Management of Pediatric Epilepsies in Asia: Expert Opinion | 作者: | WANG-TSO LEE Chan, Derrick Wei Shih Gulati, Sheffali Likasitwattanakul, Surachai Lim, Byung Chan Okumura, Akihisa Sanchez-Gan, Benilda Wang, Yi Liu, Kam Tim |
關鍵字: | Antiseizure medication; Asia; Pediatric epilepsies; Perampanel; Real-world experience | 公開日期: | 二月-2024 | 卷: | 151 | 來源出版物: | Pediatric neurology | 摘要: | Management of pediatric epilepsies poses unique challenges around diagnosis, treatment options, comorbidities, and the potential for these factors to interact with processes in the developing brain. In pediatric patients, broad-spectrum antiseizure medications (ASMs) with minimal potential for adverse events (AEs) and limited impact on cognition and behavior are preferred. Perampanel is a first-in-class ASM with broad-spectrum efficacy, a tolerable safety profile, minimal negative impact on cognitive function, and other features that make it a viable treatment option in this patient population. However, evidence and experience of its use in pediatric patients are less extensive than in adult patients. Experts in pediatric epilepsy across the region convened at a series of meetings to discuss the use of perampanel in pediatric patients, including dose optimization, AE prevention and management, and considerations in particular groups. This article summarizes key evidence for perampanel in the pediatric population and consolidates the experts' recommendations for using the ASM in managing pediatric epilepsies. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641491 | ISSN: | 08878994 | DOI: | 10.1016/j.pediatrneurol.2023.09.023 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。