https://scholars.lib.ntu.edu.tw/handle/123456789/641531
Title: | Bifidobacterium alleviate metabolic disorders via converting methionine to 5'-methylthioadenosine | Authors: | Lyu, Qiang Chen, Rou-An Chuang, Hsiao-Li Zou, Hsin-Bai Liu, Lihong Sung, Li-Kang Liu, Po-Yu Hsin-Yi Wu Chang, Hsin-Yuan Cheng, Wan-Ju WEI-KAI WU Wu, Ming-Shiang Hsu, Cheng-Chih |
Keywords: | 5’-methylthioadenosine; Bifidobacterium; LC-MS/MS metabolomics; polyphenols; postbiotic; prebiotic; probiotic | Issue Date: | 2024 | Journal Volume: | 16 | Journal Issue: | 1 | Start page/Pages: | 2300847 | Source: | Gut microbes | Abstract: | Dietary patterns and corresponding gut microbiota profiles are associated with various health conditions. A diet rich in polyphenols, primarily plant-based, has been shown to promote the growth of probiotic bacteria in the gastrointestinal tract, subsequently reducing the risk of metabolic disorders in the host. The beneficial effects of these bacteria are largely due to the specific metabolites they produce, such as short-chain fatty acids and membrane proteins. In this study, we employed a metabolomics-guided bioactive metabolite identification platform that included bioactivity testing using in vitro and in vivo assays to discover a bioactive metabolite produced from probiotic bacteria. Through this approach, we identified 5'-methylthioadenosine (MTA) as a probiotic bacterial-derived metabolite with anti-obesity properties. Furthermore, our findings indicate that MTA administration has several regulatory impacts on liver functions, including modulating fatty acid synthesis and glucose metabolism. The present study elucidates the intricate interplay between dietary habits, gut microbiota, and their resultant metabolites. |
URI: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85186846238&doi=10.1080%2f19490976.2023.2300847&origin=inward&txGid=d804a243c0bf2b63d679dbc8182e9d81 https://scholars.lib.ntu.edu.tw/handle/123456789/641531 |
ISSN: | 19490976 | DOI: | 10.1080/19490976.2023.2300847 |
Appears in Collections: | 醫學系 |
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