https://scholars.lib.ntu.edu.tw/handle/123456789/641608
標題: | Choroidal Changes in Patients with Diabetic Retinopathy: A Retrospective Study | 作者: | Peng, Shu-Yu TA-CHING CHEN YI-TING HSIEH TZYY-CHANG HO CHUNG-MAY YANG CHANG-HAO YANG |
關鍵字: | LDL; OCT; choroidal thickness; choroidal vascular index; diabetic choroidopathy; diabetic retinopathy | 公開日期: | 3-三月-2024 | 卷: | 14 | 期: | 5 | 來源出版物: | Diagnostics (Basel, Switzerland) | 摘要: | This study aimed to investigate the characteristic choroidal changes in patients with diabetic retinopathy and identify factors affecting choroidal thickness (CTh), choroidal vascular index (CVI), and choriocapillaris flow. We retrospectively analyzed 79 eyes of 48 patients with diabetes between August 2021 and February 2022. We collected laboratory data, including HbA1c, serum creatinine, blood urea nitrogen, triglyceride, total cholesterol, high-density lipoprotein, and low-density lipoprotein (LDL) levels. Optical coherence tomography images of the foveal avascular zone, retinal vascular density, choroidal flow, retinal thickness, CTh, and CVI were analyzed. Possible determining factors affecting CTh, CVI, and choriocapillaris flow were analyzed using nonparametric multivariate analysis. LDL (p < 0.001) positively correlated with CTh, whereas CVI (p = 0.007) was negatively correlated with CTh in diabetic patients with diabetes. We also identified a negative correlation between choriocapillaris flow and deep parafoveal retinal vessel density in patients with low-grade diabetic retinopathy (DR), which diminished in those with more advanced DR. Our study provides further information on the changes in choroidal structure and blood flow in patients with diabetes. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641608 | ISSN: | 2075-4418 | DOI: | 10.3390/diagnostics14050537 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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