https://scholars.lib.ntu.edu.tw/handle/123456789/641701
標題: | Investigating the Efficacy of Kidney-Protective Lactobacillus Mixture-Containing Pet Treats in Feline Chronic Kidney Disease and Its Possible Mechanism | 作者: | Tsai, Ching Wen Huang, Hsiao Wen YA-JANE LEE MING-JU CHEN |
關鍵字: | chronic kidney disease | feline | gut microbiota | Lm pet treats | probiotics | 公開日期: | 1-二月-2024 | 卷: | 14 | 期: | 4 | 來源出版物: | Animals | 摘要: | Microbiota-based strategies are a novel auxiliary therapeutic and preventative way of moderating chronic kidney disease (CKD). Lactobacillus mixture (Lm) was previously demonstrated to exert a renal-protective function in the CKD mice model. The efficacy of probiotics in pet foods is a relatively new area of study, and thus verifying the potential health benefits is necessary. This study evaluated the efficacy of Lm treats in feline CKD and elucidated the mechanisms underlying host-microbe interactions. CKD cats (2 and 3 stages) were administrated probiotic pet treats daily (10 g) for 8 weeks. The results demonstrated that during the eight weeks of Lm administration, creatinine was reduced or maintained in all cats with CKD. Similarly, gut-derived uremic toxin (GDUT), indoxyl sulfate (IS), were potential clinical significance in IS after Lm treatment (confidence intervals = 90%). The life quality of the cats also improved. Feline gut microbiome data, metabolic functional pathway, and renal function indicator analyses revealed the possible mechanisms involved in modulating CKD feline microbial composition. Further regulation of the microbial functions in amino acid metabolism after Lm administration contributed to downregulating deleterious GDUTs. The current study provides potential adjuvant therapeutic insights into probiotic pet foods or treats for pets with CKD. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185903674&doi=10.3390%2fani14040630&partnerID=40&md5=0ebb59e805d617bd5860299d2f660451 https://scholars.lib.ntu.edu.tw/handle/123456789/641701 |
ISSN: | 2076-2615 | DOI: | 10.3390/ani14040630 |
顯示於: | 動物科學技術學系 |
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