Cardiophrenic lymph nodes in advanced ovarian cancer
Journal
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Journal Volume
34
Journal Issue
1
Date Issued
2023-12-14
Author(s)
Agusti, Nuria
Bonaldo, Giulio
Kahn, Ryan M
Rosati, Andrea
Nachira, Dania
Pan, Teresa L
Mburu, Anisa
Kochiashvili, Gvantsa
Paredes, Pilar
Davies-Oliveira, Jennifer
Ramirez, Pedro T
Abstract
Epithelial ovarian cancer most commonly presents at advanced stages, and prognosis is influenced by residual disease following cytoreduction. The significance of cardiophrenic lymph node resection at the time of cytoreductive surgery in advanced ovarian cancer remains a topic of debate. Enlarged cardiophrenic lymph nodes are detected through high-resolution imaging; however, the optimal imaging technique in determining feasibility of node resection remains uncertain. Similarly, the impact of excision of cardiophrenic lymph nodes on progression-free and overall survival remains elusive. The indications for resection of cardiophrenic lymph nodes are not addressed in standard ovarian cancer guidelines. Patients with cardiophrenic lymph nodes exceeding 1 cm in size may be considered for resection if complete intra-abdominal cytoreduction is feasible to no gross residual. The surgical approach might be either by open access or by video-assisted thoracoscopic surgery (minimally invasive approach), and major complications following cardiophrenic lymph nodes resection are low. Pathological cardiophrenic lymph nodes are associated with a poorer overall prognosis and can serve as a prognostic parameter; however, the therapeutic benefit of cardiophrenic lymph nodes resection remains inconclusive.
Subjects
Lymphatic Metastasis; Ovarian Neoplasms; Surgical Oncology
Type
journal article
review