Trastuzumab deruxtecan versus treatment of physician's choice in previously treated Asian patients with HER2-low unresectable/metastatic breast cancer: subgroup analysis of the DESTINY-Breast04 study.
Journal
Breast cancer (Tokyo, Japan)
ISSN
1880-4233
Date Issued
2024-06-17
Author(s)
Yamashita, Toshinari
Sohn, Joo Hyuk
Tokunaga, Eriko
Niikura, Naoki
Park, Yeon Hee
Lee, Keun Seok
Chae, Yee Soo
Xu, Binghe
Wang, Xiaojia
Im, Seock-Ah
Li, Wei
Aguilar, Cecilia Orbegoso
Nishijima, Soichiro
Nishiyama, Yuji
Sugihara, Masahiro
Modi, Shanu
Tsurutani, Junji
Abstract
In the global phase 3 DESTINY-Breast04 study (NCT03734029), the anti-human epidermal growth factor 2 (HER2) antibody-drug conjugate trastuzumab deruxtecan (T-DXd) demonstrated a statistically significant improvement in progression-free survival (PFS) and overall survival (OS), with manageable safety compared with treatment of physician's choice (TPC) in patients with HER2-low metastatic breast cancer (mBC) who had received 1-2 prior lines of chemotherapy.
This subgroup analysis examined the efficacy and safety of T-DXd versus TPC in 213 patients from Asian countries and regions who were enrolled in the DESTINY-Breast04 trial and randomized to T-DXd (n = 147) or TPC (n = 66).
Median PFS with T-DXd and TPC was 10.9 and 5.3 months, respectively, in Asian patients with hormone receptor-positive mBC, and 10.9 and 4.6 months, respectively, in the overall Asian population. In both populations, median OS was not reached with T-DXd and was 19.9 months with TPC. The objective response rate was higher with T-DXd versus TPC in all Asian patients. Median treatment duration was 8.4 months with T-DXd and 3.5 months with TPC. The most common grade ≥ 3 drug-related treatment-emergent adverse events in Asian patients treated with T-DXd were neutropenia (16.3%), anemia (12.9%), and leukopenia (11.6%); the incidences of neutropenia and leukopenia were higher with TPC versus T-DXd. Adjudicated drug-related interstitial lung disease or pneumonitis with T-DXd was 14.3%; the majority of events were grade 1-2.
T-DXd demonstrated clinically meaningful survival benefits versus TPC in Asian HER2-low mBC patients, regardless of hormone receptor status, with no new safety signals.
ClinicalTrials.gov, NCT03734029.
Subjects
Advanced breast cancer
Asia
HER2-low
Interstitial lung disease
Trastuzumab deruxtecan
SDGs
Type
journal article