Scanning electrochemical microscopy for bioimaging
Journal
Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry
Start Page
445
End Page
452
ISBN (of the container)
9780128098943
9780128097397
Date Issued
2018
Author(s)
Abstract
Scanning electrochemical microscopy (SECM) is a scanning probe technique where typically micro- or nanoelectrodes are translated in close proximity to a specimen immersed in an electrolyte solution. The flux of redox active species between the SECM probe and the sample can be used to map local surface reactivity, to record the sample topography, or to manipulate the microenvironment of surfaces for micropatterning. Because SECM can be used in phosphate-buffered solutions with probes acting in contact-less or soft-contact mode, the technique is very attractive for the characterization of biological samples. Compared to microscopic techniques, the advantages of SECM include that the capability of extracting electrochemical information in samples and avoiding potential optical interferences, e.g., from sample color-background. © 2018 Elsevier Inc. All rights reserved.
Subjects
Bioimaging
Biosensor
Constant working distance
Contact mode scanning
Electrochemistry
Feedback mode
Generation collection mode
Live cell imaging
Microelectrode
Nanoelectrode
Redox mediator
Scanning electrochemical microscopy
Soft probe
Tissue scanning
Publisher
Elsevier
Type
book part