Neoadjuvant immunochemotherapy followed by ex situ lung auto-transplant (Oto procedure) for central lung cancer: A case report with literature review.
Journal
Respirology case reports
Series/Report No.
Respirology Case Reports
Journal Volume
12
Journal Issue
10
Start Page
Article number e70045
ISSN
2051-3380
Date Issued
2024-10
Author(s)
DOI
10.1002/rcr2.70045
Abstract
Sleeve and double-sleeve lobectomies are lung-sparing techniques for treating central lung cancers. However, if the tumour extends to involve the bronchi and vessels, lung auto-transplantation may be an alternative to pneumonectomy. Neoadjuvant therapy after surgery is the most common strategy for patients with extensive central lung cancer. Herein, we report a case of central lung cancer in a patient who underwent immunochemotherapy as neoadjuvant therapy following lung auto-transplantation. A 68-year-old man with stage IIIA non-small cell lung cancer and left upper lobe squamous cell carcinoma underwent neoadjuvant immunochemotherapy. Following partial regression, a multidisciplinary team decided on a back-table procedure with auto-lung transplantation after pneumonectomy to preserve pulmonary function. The patient had an uneventful recovery and was discharged after three weeks with no residual tumour or lymph node metastases. Lung auto-transplantation can be successfully performed in non-lung transplantation centres, potentially broadening treatment options for patients with central lung cancer.
Subjects
central lung cancer
immunochemotherapy
lung auto‐transplantation
neoadjuvant therapy
sleeve lobectomy
SDGs
Publisher
John Wiley and Sons Inc
Type
journal article